PReS13-SPK-1028: Activity and damage - we have to measure them
نویسنده
چکیده
Background Childhood-onset SLE is a complex multiorgan disease. In order to judge the need of medical intervnetions and the patient benefits from them, measurement disease activity and damage are key. Furthermore, important improvement and deterioration of disease needs to be ascertained. Such measurement are the basis for clinical trial aimed at identifying improved medications and are needed to judge the benefits of medical interventions in general.
منابع مشابه
PReS13-SPK-1582: Activity and damage - we have to measure them
“You can’t manage what you don’t measure.” The world community–led by the IMACS and PRINTO groups–has developed robust core criteria to measure disease activity and damage for Juvenile Dermatomyositis studies. These measures are tremendously useful in clinical practice, and not just for research. More problematic has been determining clinically meaningful change. The current definitions of chan...
متن کاملPReS13-SPK-1247: Activity and damage in juvenile systemic sclerosis- we have to measure them
Juvenile systemic sclerosis (jSSc) is an orphan disease. There are no established activity and damage indices fort the juvenile form. In the adult form the are prospective studies aiming to validate the activity and damage indices. The assessment of the activity and damage is important in jSSc too to be able to stage the severity of the disease, judge the response to the therapy. One of the mai...
متن کاملPReS13-SPK-1590: Relevance of cytokine in pediatric inflammatory disease
Cytokines are pleiotropic mediators that play a major role in inducing and orchestrating the inflammatory and the immune response. They play a major role in the response to damage or infections. In some pathological condition abnormal regulation of the production of cytokines leads to pathological events and subsequent damage to target tissues. Dissecting the role of each single mediator in the...
متن کاملPReS13-SPK-1592: Pediatric aspects of antiphospholipid syndrome
Introduction The antiphospholipid antibody syndrome (APS) is a multisystemic autoimmune disease characterized by thromboembolic events, pregnancy morbidity, hematologic, dermatologic, neurologic and other manifestations in the presence of elevated titers of antiphospholipid antibodies (aPL). In recent years, APS has been increasingly recognized in various pediatric autoimmune and nonautoimmune ...
متن کاملPReS13-SPK-1587: New biologic targets for the future and basic science behind them
The treatment of paediatric rheumatic diseases has made great progress in the last decade. The introduction of the biologicals meant (after the introduction of MTX) the second therapeutic revolution. This together with many improvements in related areas has greatly improved the quality of life of patients with rheumatic diseases. At present however, despite the introduction of more biological a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013